Irene M. Villasenor, Jennifer Angelada, Arlyn Canlas,
Deborah Echegoyen
Institute of Chemistry, University of the Philippines
http://doi.org/10.57043/transnastphl.1999.5771
Abstract
Isolates from yerba buena leaves were tested for their analgesic, antimutagenic, and anthelminthic activities. The acetic acid-induced writhing test showed that isolates β-sitosterol, β-sitosteryl-β-D-glucoside, and cis-8-pentadecenyllactone, at a dosage of 100 mg / kg mouse, each decreased the number of squinns induced by acetic acid by 70.0%, 73.0%, and 67.3%, respectively. β-sitosterol and an unsaturated carboxylic acid derivative are antimutagenic because they inhibited the mutagenicity of tetracycline by 65.3% and 68.7%, respectively, at a dosage of 0/01 mg/ 20 g mouse, using the in vivo Micronucleus Test. In vitro tests using Ascaris suum showed that β-sitosterol is also anthelminthic as the behavior of worms approximate that of the positive controls, Combantrin and Antiox.