{"id":5746,"date":"2026-02-19T21:12:52","date_gmt":"2026-02-19T13:12:52","guid":{"rendered":"https:\/\/transactions.nast.ph\/?p=5746"},"modified":"2026-03-26T15:36:19","modified_gmt":"2026-03-26T07:36:19","slug":"association-between-chromosome-fragile-site-and-oncogene-location-a-profile-of-filipino-head-and-neck-cancer-patients","status":"publish","type":"post","link":"https:\/\/transactions.nast.ph\/?p=5746","title":{"rendered":"Association Between Chromosome Fragile Site and Oncogene Location: A Profile of Filipino Head and Neck Cancer Patients"},"content":{"rendered":"\n

Ma. Luisa D. Enriquez, Gil M. Vicente, Rhodora R. Santos, and Filipinas F. Natividad
Research and Biotechnology Division, St. Luke’s Medical Center
Department of Biology, De La Salle University
Department of Otolaryngology, Jose Reyes Memorial Medical Center
Institute of Biology, University of the Philippines<\/p>\n\n\n\n

doi.org\/10.57043\/transnastphl.1999.5746<\/a><\/p>\n\n\n\n

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Abstract<\/strong><\/p>\n\n\n\n

Chromosome instability is often associated with predisposition to cancer. Peripheral blood lymphocytes from 25 cancer pateients and 25 control individuals were cultured for 72h. Chromatid and chromosome breaks were induced by treating lymphocytes with bleomycin, a known mutagen. Chromatids and chromosomes were scored in SO spreads for each individual. Frequency of breaks was tallied per chromosome number. A correlation was made between frequency of breaks and differential sensitivity of chromosomes to mutagen. Association between location of oncogene and fragile sites on chromosome was determined.<\/p>\n<\/div>\n\n\n\n

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Keywords<\/h5>\n\n\n
bleomycin<\/a>, <\/span>chromatid and chromosome breaks<\/a>, <\/span>fragile site<\/a>, <\/span>head and neck cancer<\/a>, <\/span>lymphocytes<\/a>, <\/span>mutagen<\/a>, <\/span>oncogene<\/a><\/div><\/div>\n<\/div>\n\n\n\n
<\/object>TNP 1999 (21)_21_Association Between Chromosome Fragile Site and Oncogene Location A Profile of Filipino Head and Neck Cancer Patients<\/a>Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

Ma. Luisa D. Enriquez, Gil M. Vicente, Rhodora R. Santos, and Filipinas F. Natividad<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[819],"tags":[961,965,963,964,960,962,966],"class_list":{"0":"post-5746","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-1999-technical-papers","7":"tag-bleomycin","8":"tag-chromatid-and-chromosome-breaks","9":"tag-fragile-site","10":"tag-head-and-neck-cancer","11":"tag-lymphocytes","12":"tag-mutagen","13":"tag-oncogene","14":"czr-hentry"},"_links":{"self":[{"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/posts\/5746"}],"collection":[{"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5746"}],"version-history":[{"count":4,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/posts\/5746\/revisions"}],"predecessor-version":[{"id":6076,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/posts\/5746\/revisions\/6076"}],"wp:attachment":[{"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}