{"id":5105,"date":"2001-01-08T14:48:00","date_gmt":"2001-01-08T06:48:00","guid":{"rendered":"https:\/\/transactions.nast.ph\/?p=5105"},"modified":"2025-02-03T15:33:20","modified_gmt":"2025-02-03T07:33:20","slug":"engineering-antibodies-for-human-therapy","status":"publish","type":"post","link":"https:\/\/transactions.nast.ph\/?p=5105","title":{"rendered":"Engineering Antibodies for Human Therapy"},"content":{"rendered":"\n<p class=\"has-text-align-center\">Eduardo A. Padlan<br>Retired Scientist<br>US National Institutes of Health<\/p>\n\n\n\n<p class=\"has-text-align-center\"><a href=\"http:\/\/doi.org\/10.57043\/transnastphl.2001.5105\" data-type=\"link\" data-id=\"http:\/\/doi.org\/10.57043\/transnastphl.2001.5105\">http:\/\/doi.org\/10.57043\/transnastphl.2001.5105<\/a><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong>Abstract<\/strong><\/p>\n\n\n\n<p>Antibodies have many potential uses in industry and medicine. Through protein engineering, the structure of an antibody can be altered and the molecule made more efficacious for human therapy. For example, the immunogenicity of a nonhuman antibody can be reduced by &#8216;humanization,&#8217; and improvements can be made on its pharmacodynamics. In addition, new properties and reactivities can be engineered into the molecule, such as multispecificity, multivalency, greater stability, etc.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\"  class=\"wp-block-file__embed\" data=\"https:\/\/transactions.nast.ph\/wp-content\/uploads\/2025\/01\/TNP-2001-23-2_3_Engineering-Antibodies-Human-Therapy.pdf\" type=\"application\/pdf\" style=\"width:100%;height:1090px\" aria-label=\"Embed of TNP 2001 (23, 2)_3_Engineering Antibodies Human Therapy.\"><\/object><a id=\"wp-block-file--media-7a4c46f0-6526-4cf1-95fa-ab4a6c5fc080\" href=\"https:\/\/transactions.nast.ph\/wp-content\/uploads\/2025\/01\/TNP-2001-23-2_3_Engineering-Antibodies-Human-Therapy.pdf\">TNP 2001 (23, 2)_3_Engineering Antibodies Human Therapy<\/a><a href=\"https:\/\/transactions.nast.ph\/wp-content\/uploads\/2025\/01\/TNP-2001-23-2_3_Engineering-Antibodies-Human-Therapy.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-7a4c46f0-6526-4cf1-95fa-ab4a6c5fc080\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Eduardo A. Padlan<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[611,612],"tags":[],"class_list":{"0":"post-5105","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-611","7":"category-2001-plenary-papers","8":"czr-hentry"},"_links":{"self":[{"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/posts\/5105"}],"collection":[{"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5105"}],"version-history":[{"count":2,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/posts\/5105\/revisions"}],"predecessor-version":[{"id":5258,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=\/wp\/v2\/posts\/5105\/revisions\/5258"}],"wp:attachment":[{"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/transactions.nast.ph\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}